Creatinine Amidohydrolase Microbial Sarcosine Oxidase Microbial UCSF clinical Labs of 6 Proc/ iSTAT /Creat. Contents Each i-STAT cartridge contains one reference electrode (when potentiometric sensors are included in the cartridge configuration), sensors for the measurement of specific analytes, and a buffered aqueous calibrant solution that contains known concentrations of analytes and preservatives.ģ For cartridges that contain a sensor for the measurement of Creatinine, a list of reactive ingredients is indicated below: i STAT Creatinine Chemistry China Basin Reactive Ingredient Biological Source Creatinine N/A Creatine Amidinohydrolase Actinobacillus sp. INTENDED USE The test for Creatinine, as part of the i-STAT System, is intended for use in the in vitro quantification of Creatinine in arterial, venous, or capillary whole blood. Certain substances, such as drugs, may affect analyte levels in If results appear inconsistent with the clinical assessment, the patient sample should be retested using another cartridge. The liberated hydrogen peroxide is oxidized at the platinum electrode to produce a current which is proportional to the sample Creatinine concentration.Ģ See below for information on factors affecting results. The oxidation of sarcosine, catalyzed by the enzyme sarcosine oxidase, produces hydrogen peroxide (H2O2). Creatine is then hydrolyzed to sarcosine in a reaction catalyzed by the enzyme creatine amidinohydrolase. Creatinine is hydrolyzed to creatine in a reaction catalyzed by the enzyme Creatinine amidohydrolase.
The same is true if the levels go to 5.0 or higher in an adult.1 UCSF clinical Labs of 6 Proc/ iSTAT /Creat. A baby who has a level of 2.0 or higher mostly likely has a serious kidney disease. However, the levels in a person who has only one kidney may be as high as 1.8 or 1.9. Normal blood levels are 0.6 to 1.2 milligrams per deciliter in men and and 0.5 to 1.1 dL in women. The normal levels of creatinine are not universal but depend on the personâs age, gender, race and size. The bloodstream carries creatinine to the kidneys, and the kidneys help to excrete it via the urine. This breakdown is a result of the normal stresses on the muscles, so everybody has some level of creatinine in their blood. Useful InformationĬreatinine is a substance that is a by-product of the breakdown of an amino acid called creatine. Corticosteroids are sometimes given to support muscle strength. Treatment depends on what is causing the low creatinine level. Diseases that cause wasting of the muscles, such as muscular dystrophy, put a person at risk for a low creatinine level.
Most of these people do not have much muscle mass.
People with liver disease are also at risk, for the liver produces creatine. Very old people and babies tend to have low creatinine levels as do people who are malnourished, have lost a great deal of weight or who have been sick for a long time. For men, 0.6 - 1.2 mg/dl are considered normal, while for woman values between 0.5 - 1.1 mg/dl are within normal range. Please note: gender influences the normal range of the creatinine level. Increase your Creatinine by 0.1 mg/dl to be within normal range.
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